Analysis of therapeutic targets and prognostic biomarkers of CXC chemokines in cervical cancer microenvironment

Abstract Background The tumor microenvironment (TME) has received an increasing amount of attention. CXC chemokines can regulate immune cell transport and activity to exert anti-tumor immunity. However, studies on the expression prognosis in cervical cancer (CC) are more limited. Methods study investigated role TME CC by using public databases. Moreover, quantitative real-time PCR (qRT-PCR) immunohistochemistry (IHC) were performed further verify. Results transcriptional levels CXCL1/3/5/6/8/9/10/11/13/16/17 tissues significantly elevated while CXCL12/14 reduced. We reached a consistent conclusion that CXCL9/10/11/13 was verified immunohistochemistry. patients with low CXCL1/2/3/4/5/8 associated longer overall survival (OS). CCL family related neighboring alteration. RELA, NFKB1, LCK PAK2 key transcription factors kinase targets chemokines, respectively. also found there significant correlations between CXCL9/10/11 infiltration cells (CD8+ T cell, CD4+ neutrophils dendritic cells). Conclusions In brief, we conducted comprehensive analysis via clinical data some online Our results may provide new idea for selection immunotherapeutic prognostic biomarkers cancer.